第一篇：梅琳達(dá) 蓋茨2013杜克大學(xué)畢業(yè)典禮演講視頻

梅琳達(dá)·蓋茨2013杜克大學(xué)畢業(yè)典禮演講

梅琳達(dá)·蓋茨（Melinda French Gates，1964~），畢業(yè)于美國(guó)杜克大學(xué)計(jì)算機(jī)系，后獲得MBA學(xué)位，然后如愿進(jìn)入了自己曾經(jīng)實(shí)習(xí)過的微軟公司，很快嶄露頭角，取得了驕人的業(yè)績(jī)，成為一名管理人員。在嫁給比爾·蓋茨之前，梅琳達(dá)已經(jīng)在微軟做出了驕人的業(yè)績(jī)。她擔(dān)任一個(gè)部門的主管，手下有一百多名員工。在嫁給蓋茨之后，梅琳達(dá)便做起了專職的太太。幾年來，她為蓋茨生下一雙兒女，還管理著蓋茨豪宅的日常工作。梅琳達(dá)把家里收拾得十分溫馨，還建了一個(gè)家庭圖書館。梅琳達(dá)和蓋茨一起建立了美國(guó)有史以來最大的基金會(huì)——蓋茨基金會(huì)，并擔(dān)任主席。

人際關(guān)系是一切（演講稿）

梅琳達(dá)·蓋茨在杜克大學(xué)2013屆畢業(yè)典禮上的演講，身為杜克大學(xué)的校友，梅琳達(dá)在母校發(fā)表了畢業(yè)典禮演講，并鼓勵(lì)2013屆畢業(yè)生去認(rèn)識(shí)“所有人的無限尊嚴(yán)”。

她這次演講的主題是聯(lián)系。她認(rèn)為互聯(lián)網(wǎng)的發(fā)展能夠?yàn)槿澜缰g人的聯(lián)系提供一個(gè)非常好的平臺(tái)，能讓人把與自己生活在不同環(huán)境中的人，理解為和自己本質(zhì)上一樣的人，建立起直接溝通的橋梁。比起抽象的概念，這種具體聯(lián)系，能讓人更愿意去幫助那些同自己一樣，但生活條件更糟糕的人。這樣一來人類才有可能真正實(shí)現(xiàn)馬丁·路德·金所說的所有人情同手足的世界。

梅琳達(dá)·蓋茨2013杜克大學(xué)畢業(yè)典禮英語演講稿：

President Brodhead, Trustees, members of the Duke University Community, thank you for inviting me to come back to my alma mater for this important occasion.I am grateful for the honorary degree, and moved by the opportunity to address the graduating seniors.To the Class of 2013: Let me start by saying congratulations......and by reminding you to thank your mothers and wish them a happy Mothers' Day......and by admitting that I'm still bitter about the Louisville game.I was a student here in 1986 when Coach K took the team to the finals for the first time.We lost to Louisville then, too, so you and I share that particular agony.However, you had the good fortune to be here on campus when Duke won its fourth national championship.I never got to see us cut down the nets, but I did see us beat UNC, in Chapel Hill, when Michael Jordan was the star of the team.The fact that Michael Jordan recently turned 50 years old tells you how long it's been since I was a student.No matter how much time passes, though, I always feel connected to Duke.I love visiting my favorite landmarks, especially the Duke Gardens, where I used to go when I was stressed out before exams and needed to clear my head.I went yesterday, because I wanted to make sure I was centered before giving this speech.There's also my feeling of deep connection to the community my classmates created during our four years, and to the lifelong friends I made here--in short, to the people.I doubt there is a word that captures the combination of experiences and places and people that we summarize under the label “Duke.” The best one I can think of is “connected.” And this is a word I'd like to talk about for a few minutes on your Commencement Day.In August, 1982, I left my home in Dallas, Texas, to come here to Durham.To mark this rite of passage, my parents gave me a terrific present: the cutting-edge Olympus B12 portable typewriter, with a carrying case included.One of its best features was how light it was: Amazingly, the whole bundle weighed just 12 pounds!

It was during my time at Duke that the personal computer displaced the typewriter as the technology of choice on campus.Those of us in the computer science department actually resented the change.There were so few computers available, and all of a sudden the humanities majors were hogging our machines to write their papers.We had to do our programming in the middle of the night, usually in the creepy basement of the old biological science building.We'd set up contests--who programmed the fastest or made the fewest mistakes--kind of like a prehistoric hack-a-thon.The punishment for the losers was a trip to the biology lab at the end of the hall, where they had to touch the scariest mutant frog specimens.CONNECTION, AN INTRODUCTION

The personal computer--and later, after I'd graduated and taken a job at Microsoft, the Internet--started a communications revolution.My kids are a few years younger than you, but raising them has proved to me that the way you communicate is the single biggest difference between you now and me a generation ago.One popular way of describing this aspect of your lives is to say that you're “connected.” Some pundits have even started to refer to you as Generation C.One recent report overdid the c-thing by saying you are “connected, communicating, content-centric, community-oriented, always clicking.” It went on to say that, for these reasons alone, you will “transform the world as we know it.”

Of course, all the hype about how connected you are has contributed to a counter-narrative--that, in fact, your generation is increasingly disconnected from the things that matter.The arguments go something like this: Instead of spending time with friends, you spend it alone, collecting friend requests.Rather than savoring your food, you take pictures of it and post them on Facebook.I want to encourage you to reject the cynics who say technology is flattening your experience of the world.Please don't let anyone make you believe you are somehow shallow because you like to update your status on a regular basis.The people who say technology has disconnected you from others are wrong.So are the people who say technology automatically connects you to others.Technology is just a tool.It's a powerful tool, but it's just a tool.Deep human connection is very different.It's not a tool.It's not a means to an end.It is the end--the purpose and the result of a meaningful life--and it will inspire the most amazing acts of love, generosity, and humanity.In his famous speech “Remaining Awake Through a Great Revolution,” Martin Luther King Jr.said, “Through our scientific and technological genius, we have made of this world a neighborhood and yet we have not had the ethical commitment to make of it a brotherhood.”

With 50 years of hindsight, I think it's fair to say Dr.King was premature in calling the world a neighborhood.Back then, Americans lumped whole continents into something they referred to as the Third World, as if the people on the other side of the planet were an undifferentiated mass whose defining feature was that they were not like us.But as a result of the ongoing communications revolution, your world really can be a neighborhood.So the ethical commitment Dr.King spoke of is yours to live up to.What does it mean to make of this world a brotherhood and a sisterhood? That probably sounds like a lot to ask of you as individuals, or even as a graduating class.I'm pretty sure none of you will respond to the annoying question “What are you going to do after graduation?” by saying “I plan to have the ethical commitment to make of this world a brotherhood.”

But you can change the way you think about other people.You can choose to see their humanity first--the one big thing that makes them the same as you, instead of the many things that make them different from you.It is not just a matter of caring about people.I assume you already do that.It's much harder to see all people, including people whose experiences are very different from yours, as three-dimensional human beings who want and need the same things you do.But if you can really believe that all 7 billion people on the planet are equal to you in spirit, then you will take action to make the world more equal for everyone.PAUL FARMER, TESTAMENT TO CONNECTION

Paul Farmer, the Duke graduate I admire most, is a testament to the deep human connection I'm talking about.As many of you know, Paul, who's here today, is a doctor and global health innovator.For years, he traveled back and forth from Boston, where he is a professor of medicine, to Haiti, where he ran a health clinic giving the highest quality care to the poorest people in the world.Now, he lives mostly in Rwanda, where he's working on changing the country's entire health care system.I first met Paul in 2003, when I went to see him in Haiti.It took us forever to walk the 100 yards from our vehicle to the clinic because he introduced me to every single person we met along the way.I am not exaggerating.Every single person.As we moved along, he introduced each person to me by first and last name, wished their families well, and asked for an update about their lives.He hugged people when he greeted them and looked them in the eyes throughout each conversation.If you believe love plays a role in healing, there was healing happening at every step of that journey.When we finally reached the waiting area outside the clinic, I saw a lovely garden with a canopy of flowering vines.Paul told me he built it himself, for two reasons.First, he said, it gets hot, and he wants to his patients to be cool in the shade while they wait.Second, he wants them to see what he sees, the beauty of the world, before they have to go into the clinic for treatment.The next day, I visited a different clinic in Haiti.The clinic was there for the same reason as Paul's--to provide poor people with the medical care they desperately need but cannot afford.The doctors worked there for all the right reasons.But I noticed that the patients were waiting outside in the scorching sun.Inside, it felt like the doctors considered themselves health providers, and the patients were recipients.There was no sense, as there was in Paul's clinic, of an equal partnership with the community.Experiencing those two clinics one right after the other showed me that Paul made a moral choice to do the hard work of deep connection.He took the time to do the little things: provide shade, remember surnames, and make eye contact.These small acts were born of a big idea--the boundless dignity of all people.

第二篇：梅琳達(dá) 蓋茨2013杜克大學(xué)畢業(yè)典禮演講視頻

梅琳達(dá) 蓋茨2013杜克大學(xué)畢業(yè)典禮演講視頻：

人際關(guān)系是一切（演講稿）

梅琳達(dá)·蓋茨在杜克大學(xué)2013屆畢業(yè)典禮上的演講，身為杜克大學(xué)的校友，梅琳達(dá)在母校發(fā)表了畢業(yè)典禮演講，并鼓勵(lì)2013屆畢業(yè)生去認(rèn)識(shí)“所有人的無限尊嚴(yán)”。

梅琳達(dá)·蓋茨2013杜克大學(xué)畢業(yè)典禮英語演講稿：

President Brodhead, Trustees, members of the Duke University Community, thank you for inviting me to come back to my alma mater for this important occasion.I am grateful for the honorary degree, and moved by the opportunity to address the graduating seniors.To the Class of 2013: Let me start by saying congratulations......and by reminding you to thank your mothers and wish them a happy Mothers' Day......and by admitting that I'm still bitter about the Louisville game.I was a student here in 1986 when Coach K took the team to the finals for the first time.We lost to Louisville then, too, so you and I share that particular agony.However, you had the good fortune to be here on campus when Duke won its fourth national championship.I never got to see us cut down the nets, but I did see us beat UNC, in Chapel Hill, when Michael Jordan was the star of the team.The fact that Michael Jordan recently turned 50 years old tells you how long it's been since I was a student.No matter how much time passes, though, I always feel connected to Duke.I love visiting my favorite landmarks, especially the Duke Gardens, where I used to go when I was stressed out before exams and needed to clear my head.I went yesterday, because I wanted to make sure I was centered before giving this speech.There's also my feeling of deep connection to the community my classmates created during our four years, and to the lifelong friends I made here--in short, to the people.I doubt there is a word that captures the combination of experiences and places and people that we summarize under the label “Duke.” The best one I can think of is “connected.” And this is a word I'd like to talk about for a few minutes on your Commencement Day.In August, 1982, I left my home in Dallas, Texas, to come here to Durham.To mark this rite of passage, my parents gave me a terrific present: the cutting-edge Olympus B12 portable typewriter, with a carrying case included.One of its best features was how light it was: Amazingly, the whole bundle weighed just 12 pounds!

It was during my time at Duke that the personal computer displaced the typewriter as the technology of choice on campus.Those of us in the computer science department actually resented the change.There were so few computers available, and all of a sudden the humanities majors were hogging our machines to write their papers.We had to do our programming in the middle of the night, usually in the creepy basement of the old biological science building.We'd set up contests--who programmed the fastest or made the fewest mistakes--kind of like a prehistoric hack-a-thon.The punishment for the losers was a trip to the biology lab at the end of the hall, where they had to touch the scariest mutant frog specimens.CONNECTION, AN INTRODUCTION

The personal computer--and later, after I'd graduated and taken a job at Microsoft, the Internet--started a communications revolution.My kids are a few years younger than you, but raising them has proved to me that the way you communicate is the single biggest difference between you now and me a generation ago.One popular way of describing this aspect of your lives is to say that you're “connected.” Some pundits have even started to refer to you as Generation C.One recent report overdid the c-thing by saying you are “connected, communicating, content-centric, community-oriented, always clicking.” It went on to say that, for these reasons alone, you will “transform the world as we know it.”

Of course, all the hype about how connected you are has contributed to a counter-narrative--that, in fact, your generation is increasingly disconnected from the things that matter.The arguments go something like this: Instead of spending time with friends, you spend it alone, collecting friend requests.Rather than savoring your food, you take pictures of it and post them on Facebook.I want to encourage you to reject the cynics who say technology is flattening your experience of the world.Please don't let anyone make you believe you are somehow shallow because you like to update your status on a regular basis.The people who say technology has disconnected you from others are wrong.So are the people who say technology automatically connects you to others.Technology is just a tool.It's a powerful tool, but it's just a tool.Deep human connection is very different.It's not a tool.It's not a means to an end.It is the end--the purpose and the result of a meaningful life--and it will inspire the most amazing acts of love, generosity, and humanity.In his famous speech “Remaining Awake Through a Great Revolution,” Martin Luther King Jr.said, “Through our scientific and technological genius, we have made of this world a neighborhood and yet we have not had the ethical commitment to make of it a brotherhood.”

With 50 years of hindsight, I think it's fair to say Dr.King was premature in calling the world a neighborhood.Back then, Americans lumped whole continents into something they referred to as the Third World, as if the people on the other side of the planet were an undifferentiated mass whose defining feature was that they were not like us.But as a result of the ongoing communications revolution, your world really can be a neighborhood.So the ethical commitment Dr.King spoke of is yours to live up to.What does it mean to make of this world a brotherhood and a sisterhood? That probably sounds like a lot to ask of you as individuals, or even as a graduating class.I'm pretty sure none of you will respond to the annoying question “What are you going to do after graduation?” by saying “I plan to have the ethical commitment to make of this world a brotherhood.”

But you can change the way you think about other people.You can choose to see their humanity first--the one big thing that makes them the same as you, instead of the many things that make them different from you.It is not just a matter of caring about people.I assume you already do that.It's much harder to see all people, including people whose experiences are very different from yours, as three-dimensional human beings who want and need the same things you do.But if you can really believe that all 7 billion people on the planet are equal to you in spirit, then you will take action to make the world more equal for everyone.PAUL FARMER, TESTAMENT TO CONNECTION

Paul Farmer, the Duke graduate I admire most, is a testament to the deep human connection I'm talking about.As many of you know, Paul, who's here today, is a doctor and global health innovator.For years, he travelled back and forth from Boston, where he is a professor of medicine, to Haiti, where he ran a health clinic giving the highest quality care to the poorest people in the world.Now, he lives mostly in Rwanda, where he's working on changing the country's entire health care system.I first met Paul in 2003, when I went to see him in Haiti.It took us forever to walk the 100 yards from our vehicle to the clinic because he introduced me to every single person we met along the way.I am not exaggerating.Every single person.As we moved along, he introduced each person to me by first and last name, wished their families well, and asked for an update about their lives.He hugged people when he greeted them and looked them in the eyes throughout each conversation.If you believe love plays a role in healing, there was healing happening at every step of that journey.When we finally reached the waiting area outside the clinic, I saw a lovely garden with a canopy of flowering vines.Paul told me he built it himself, for two reasons.First, he said, it gets hot, and he wants to his patients to be cool in the shade while they wait.Second, he wants them to see what he sees, the beauty of the world, before they have to go into the clinic for treatment.The next day, I visited a different clinic in Haiti.The clinic was there for the same reason as Paul's--to provide poor people with the medical care they desperately need but cannot afford.The doctors worked there for all the right reasons.But I noticed that the patients were waiting outside in the scorching sun.Inside, it felt like the doctors considered themselves health providers, and the patients were recipients.There was no sense, as there was in Paul's clinic, of an equal partnership with the community.Experiencing those two clinics one right after the other showed me that Paul made a moral choice to do the hard work of deep connection.He took the time to do the little things: provide shade, remember surnames, and make eye contact.These small acts were born of a big idea--the boundless dignity of all people.

第三篇：關(guān)于申請(qǐng)比爾及梅琳達(dá)蓋茨基金會(huì)-2012

關(guān)于申請(qǐng)比爾及梅琳達(dá)蓋茨基金會(huì)“探索大挑戰(zhàn)”項(xiàng)目通知

各位老師、同學(xué)：

總金額達(dá)一億美元的“探索大挑戰(zhàn)”（Grand Challenges Explorations，簡(jiǎn)稱“GCE”）是蓋茨基金會(huì)全球發(fā)展與健康領(lǐng)域的項(xiàng)目之一。它面向全球征集并資助大膽而非傳統(tǒng)性的研究計(jì)劃，旨在探索和發(fā)現(xiàn)突破性的創(chuàng)新方案，從而幫助應(yīng)對(duì)那些給發(fā)展中國(guó)家人民帶來最大傷害、卻很少為人所關(guān)注的重大疾病和發(fā)展問題。

本項(xiàng)目鼓勵(lì)來自全球各個(gè)地區(qū)、各個(gè)學(xué)科、不同年齡的個(gè)人或組織提交申請(qǐng)，同時(shí)也歡迎非健康領(lǐng)域的個(gè)人、團(tuán)體或企業(yè)積極參與。同時(shí)，“探索大挑戰(zhàn)”最大程度地簡(jiǎn)化申請(qǐng)流程——申請(qǐng)者只需登錄GCE官方網(wǎng)站，在線提交兩頁紙的英文申請(qǐng)，并不要求提供初步研究數(shù)據(jù)資料。即使在申請(qǐng)國(guó)際資助上沒有任何經(jīng)驗(yàn)的年輕創(chuàng)新者，也可以方便地申請(qǐng)。

探索大挑戰(zhàn)(GCE)支持著數(shù)百個(gè)處于早期階段的項(xiàng)目——包括許多此前沒有機(jī)會(huì)實(shí)踐的創(chuàng)意——以及來自廣闊學(xué)科領(lǐng)域和世界各地的專家。方案一旦入選，即可獲得蓋茨基金會(huì)十萬美元的資金支持，有望取得成果的項(xiàng)目還有機(jī)會(huì)申請(qǐng)第二輪一百萬美元的追加資助。

第九輪申請(qǐng)現(xiàn)已啟動(dòng)，本輪征集主題請(qǐng)參閱《比爾及梅琳達(dá)蓋茨基金會(huì)“探索大挑戰(zhàn)”項(xiàng)目申請(qǐng)指南》。申請(qǐng)的截止時(shí)間為北京時(shí)間2012年05月16日凌晨2:30（美國(guó)太平洋時(shí)間05月15日中午11:30）。

歡迎老師與同學(xué)們踴躍申請(qǐng)！

如欲了解探索大挑戰(zhàn)更多信息，歡迎訪問“探索大挑戰(zhàn)”英文官網(wǎng)： http://）的可衡量的進(jìn)展。（本基金特別關(guān)注千年發(fā)展目標(biāo)1，4，5和6號(hào)）● 創(chuàng)新的傳播機(jī)制，將實(shí)例，數(shù)據(jù)以及信息傳播給核心受眾。

● 能夠激勵(lì)主動(dòng)參與和協(xié)作解決問題的概念。例如游戲，眾包項(xiàng)目，以及其他能夠使整個(gè)領(lǐng)域由單向溝通轉(zhuǎn)向全身心參與的項(xiàng)目。

● 能夠使挑戰(zhàn)及其解決手段更加人性化的革命性手段，并把提供援助和接受援助的社區(qū)聯(lián)結(jié)起來。

有下列情況的項(xiàng)目我們不考慮資助

● 與本基金會(huì)的全球健康（http://004km.cn/global-health/Pages/overview.aspx）與全球發(fā)展目標(biāo)（http://004km.cn/global-development/Pages/overview.aspx）不符合的項(xiàng)目

● 僅有方案文本，缺乏強(qiáng)健的行動(dòng)規(guī)劃支持。

● 針對(duì)具體災(zāi)害應(yīng)急響應(yīng)、個(gè)體捐助、以及緊急救援的項(xiàng)目?！?沒有對(duì)解決當(dāng)前傳播問題具有清洗目標(biāo)的基礎(chǔ)性研究

● 純粹的行為矯正或教育項(xiàng)目。（例如，培訓(xùn)項(xiàng)目，獎(jiǎng)學(xué)金，教育項(xiàng)目等）● 純粹的基礎(chǔ)設(shè)施或能力建設(shè)措施。

● 將基金經(jīng)費(fèi)指定用于游說活動(dòng)的項(xiàng)目（例如，試圖影響立法或立法行動(dòng)）或試圖影響公職選舉的。

我們?nèi)绾卧u(píng)估申請(qǐng)

我們將根據(jù)下列規(guī)則來評(píng)估申請(qǐng)：

● 響應(yīng)主題：申請(qǐng)書有無針對(duì)主題所涉及的問題？請(qǐng)注意上文所列舉的我們不贊助的情況。

● 創(chuàng)造性：申請(qǐng)書是否為解決主題所涉問題提出了非傳統(tǒng)的或者富有創(chuàng)意的方案？申請(qǐng)書是否描述了其計(jì)劃與現(xiàn)有手段的不同之處，有否提出新的考察標(biāo)準(zhǔn)，有否預(yù)設(shè)一個(gè)衡量成功與否的合理目標(biāo)？

四、本期主題——探索抗瘧疾化合物的新途徑

機(jī)遇：

通過對(duì)數(shù)百萬有專利保護(hù)以及公共資源的化合物進(jìn)行廣泛的高通量篩選，研究人員已發(fā)現(xiàn)數(shù)千種對(duì)紅內(nèi)期瘧原蟲（Plasmodium falciparum）明確有抑制性功能的抗瘧疾化合物。為了促進(jìn)對(duì)抗瘧疾藥物的進(jìn)一步開發(fā)，這些化合物的結(jié)構(gòu)和相關(guān)說明已在文獻(xiàn)和公共數(shù)據(jù)庫(kù)中向公眾開放。最近，抗瘧疾藥物基金會(huì)（MMV）從圣裘德兒童研究醫(yī)院、諾華公司和葛蘭素-史克公司的化學(xué)藥品資料庫(kù)中選取了400種化合物，建立了一個(gè)可供進(jìn)一步研究使用的“瘧疾信息庫(kù)”（“Malaria Box”: 004km.cn/malariabox），信息庫(kù)中包含有200種類藥物化合物，這些可以作為研發(fā)口服藥物的基礎(chǔ)，以及200種類探針化合物，作為生物工具使用可以代表最廣泛的化學(xué)多樣性。

這代表著全球傳染性疾病研究領(lǐng)域里的一個(gè)史無前例的契機(jī)：大量的化學(xué)生物信息和藥物研究的早期信息可以共享，并服務(wù)于新一代抗瘧疾藥物的開發(fā)，這對(duì)于實(shí)現(xiàn)消滅瘧疾的目標(biāo)至關(guān)重要。

我們?cè)趯で螅?/p>

本主題的目標(biāo)在于資助非傳統(tǒng)的、革新性的途徑、方法和檢驗(yàn)手段，用于對(duì)抗瘧疾化合物的分析、定性和排序，并為研發(fā)新一代瘧疾藥物收集更多信息。我們希望能夠鼓勵(lì)研究者開發(fā)和使用創(chuàng)新的生物、化學(xué)、計(jì)算機(jī)學(xué)和系統(tǒng)性的方法來篩選抗瘧疾化合物，從而實(shí)現(xiàn)對(duì)目前公開的抗瘧疾化合物信息庫(kù)利用的最大化，促進(jìn)化合物的選擇與開發(fā)。很多征集來的方法也許能應(yīng)用于更廣泛的藥物研發(fā)領(lǐng)域，我們鼓勵(lì)研究者整合為實(shí)現(xiàn)本主題目標(biāo)而應(yīng)用的新工具和新方法，應(yīng)用創(chuàng)新思維，使得這些新方法能夠服務(wù)于發(fā)展中國(guó)家并滿足其需求。

為了初步檢驗(yàn)?zāi)愕难芯吭O(shè)想，訪問抗瘧疾化合物數(shù)據(jù)庫(kù)的權(quán)限需要進(jìn)行申請(qǐng)?？汞懠菜幬锘饡?huì)將向成功的申請(qǐng)者開放“瘧疾數(shù)據(jù)包”，而對(duì)于那些確實(shí)需要分析更大規(guī)?；衔飵?kù)的項(xiàng)目，葛蘭素-史克公司將對(duì)其開放擁有13,500種化合物的克雷斯坎托斯抗瘧疾化合物數(shù)據(jù)庫(kù)（TCAMS）。當(dāng)然，獲得這些化合物數(shù)據(jù)庫(kù)使用權(quán)限的研究者，也必須公開其研究結(jié)果。

需要額外專家支持、工具和/或科研輔助以達(dá)到其研究目標(biāo)的申請(qǐng)者，可以在項(xiàng)目的第二期（定義見探索大挑戰(zhàn)官方網(wǎng)站（“Grand Challenges Explorations website”: 004km.cn/Explorations/Pages/Introduction.aspx））申請(qǐng)和葛蘭素-史克公司克雷斯坎托斯開放實(shí)驗(yàn)室（“GlaxoSmithKline Tres Cantos Open Lab”: 004km.cn）建立合作關(guān)系。

請(qǐng)注意：撰寫項(xiàng)目申請(qǐng)書，請(qǐng)勿聯(lián)系抗瘧疾藥物基金會(huì)和/或葛蘭素-史克公司。請(qǐng)慎重考慮與本主題目標(biāo)不符的研究活動(dòng)（見下文“有以下情況的項(xiàng)目我們不考慮資助”部分）

我們會(huì)考慮資助的項(xiàng)目示例：

能夠穩(wěn)健高效地對(duì)抗瘧疾化合物進(jìn)行分析、分類和排序的新型瘧疾檢測(cè)流程和技術(shù)。能夠?qū)Χ喾N化合物系列進(jìn)行綜合特征鑒定和排序的新方法，如評(píng)估藥物作用速度，協(xié)同作用，確認(rèn)新的腳手架蛋白，或是確定抗瘧疾藥物的作用機(jī)制的新方法。

有以下情況的項(xiàng)目我們不考慮資助：利用藥物化學(xué)方法優(yōu)化抗瘧疾化合物，或通過標(biāo)準(zhǔn)藥物開發(fā)流程（藥物分類、初始活性化合物確證或先導(dǎo)化合物優(yōu)化）提升化合物的類藥物性能。

1.Gamo et al.Thousands of chemical starting points for antimalarial lead identification.Nature.2010;465:305-10.2.Guiguemde et al.Chemical genetics of Plasmodium falciparum.Nature.2010;465:311-5.3.http://004km.cn/malariabox and at the FAQs page 004km.cn/research-development/malaria-box-faqs 與本主題目標(biāo)無顯著關(guān)系的基礎(chǔ)研究。5.The malERA Consultative Group on Drugs(2011).A Research Agenda for Malaria Eradication: Drugs.PLoS Med.2011;8.五、本期主題——減少農(nóng)作物在儲(chǔ)存運(yùn)輸過程中的損失

背景：

在發(fā)展中國(guó)家，不論是在田間還是市場(chǎng)，生物脅迫如病毒、真菌、細(xì)菌、雜草、昆蟲和其他害蟲和病原體都是制約農(nóng)業(yè)生產(chǎn)力發(fā)展的一個(gè)主要因素。發(fā)展中國(guó)家從事小型農(nóng)業(yè)生產(chǎn)的農(nóng)戶，無論是在收成前或豐收之后，由于缺少對(duì)抗或防范這些生物脅迫的資源，因而最容易受到它們的侵害，甚至遭受毀滅性的農(nóng)作物損失。

目前，大多數(shù)農(nóng)作物保護(hù)策略都包括通過基因改良提高作物抵抗害蟲和病原體的能力，或者使用化學(xué)制劑驅(qū)散害蟲。但是在蟲害嚴(yán)重的區(qū)域，例如撒哈拉以南非洲的熱帶地區(qū)，如果新型農(nóng)作物改良品種僅有單一來源的基因抗性，往往在貧困農(nóng)戶還沒有獲得這些改良品種之前或在他們剛剛拿到之后不久，它們的基因抗性就已經(jīng)不再對(duì)生物脅迫起作用了。盡管有些農(nóng)戶的確使用化學(xué)除草劑和殺蟲劑，但是卻沒有經(jīng)過專門的訓(xùn)練，因而導(dǎo)致無效或不安全使用。

對(duì)于小型農(nóng)戶來說，在收獲季節(jié)之后對(duì)農(nóng)作物造成破壞的害蟲和病原體給他們?cè)斐傻拇驌敉瑯邮请y以承受的。收貨后的損失意味著家中剩余作物無法被賣出，不僅影響了農(nóng)戶們的生計(jì)，還迫使他們不得不自己吃完那些被污染的作物。這些限制不光直接沖擊著農(nóng)戶家庭自身，也影響到他們所在的社區(qū)和國(guó)家的糧食安全。

挑戰(zhàn)： 本議題的目的是為發(fā)展中國(guó)家的小型農(nóng)戶尋求變革性的解決方案，幫助他們應(yīng)對(duì)害蟲和病原體帶來的危害。我們鼓勵(lì)研究人員和企業(yè)家，利用生物學(xué)和工程學(xué)的新興信息和工具促進(jìn)農(nóng)業(yè)發(fā)展，并通過重點(diǎn)研究植株、害蟲、病菌、雜草、以及/或它們之間的相互作用，找到對(duì)現(xiàn)行方法進(jìn)行革命性變革的途徑。提案內(nèi)無需提供初步數(shù)據(jù)，而應(yīng)清晰地證明與體現(xiàn)該提案在創(chuàng)新層面的意義，以及其促成根本變革的潛質(zhì)。

請(qǐng)注意，申請(qǐng)?zhí)岚副仨毰c基金會(huì)農(nóng)業(yè)發(fā)展團(tuán)隊(duì)的目標(biāo)保持一致。因此，我們所尋求的提案應(yīng)該能夠：

? 為保護(hù)農(nóng)作物免受生物脅迫提供創(chuàng)新與具有變革性的方案；

? 在未來的十到二十年內(nèi)能大力提高發(fā)展中國(guó)家小型農(nóng)戶的可持續(xù)生產(chǎn)力； ? 跟目前的作物保護(hù)措施相比，提供一種大幅降低成本或提高效率的可能性； ? 適用于以下一種或多種作物：玉米，小麥，大米，小米，高粱，木薯，紅薯，山藥，豆，豇豆，鷹嘴豆，花生； ? 針對(duì)某種或某些特定的生物脅迫； ? 傳達(dá)一個(gè)清晰且可驗(yàn)證的假說。

以下是會(huì)被列入考慮的幾個(gè)范例： ? 生物、化學(xué)和生物化學(xué)領(lǐng)域以外的應(yīng)用方向，包括：工程，物理科學(xué)，大氣科學(xué)，流行病學(xué)，計(jì)算機(jī)科學(xué)及其他

? 生物防治

? 新型分子或基因手段

? 創(chuàng)新的作物管理或綜合蟲害管理措施 ? 用于收獲后作物保護(hù)的生物和工程解決方案；

? 使更廣泛的環(huán)境可持續(xù)性與農(nóng)作物保護(hù)有機(jī)銜接的新戰(zhàn)略； ? 其他沒有在此強(qiáng)調(diào)的應(yīng)用方向

我們不會(huì)考慮資助以下申請(qǐng)：

? 針對(duì)目前作物保護(hù)措施既有的知識(shí)與應(yīng)用所做的漸進(jìn)式改進(jìn)；

? 不直接與發(fā)展中國(guó)家相關(guān)的提案；

? 不適用于下列作物提案：玉米、小麥、大米、小米、高粱、木薯、紅薯、山藥、豆類、鷹嘴豆和落花生；

? 對(duì)現(xiàn)今受管制化學(xué)品的改良，或開發(fā)新的將會(huì)被定為受管制化學(xué)品的化學(xué)配方； ? 維持型作物育種，例如利用既成的遺傳或標(biāo)準(zhǔn)育種技術(shù)在已知的種質(zhì)庫(kù)里進(jìn)行性狀選擇；

? 把現(xiàn)有技術(shù)轉(zhuǎn)移至新的系統(tǒng)，而未進(jìn)行創(chuàng)新改良（譬如：把既成的植物抗逆基因插入不同的物種）；

? 種子、化學(xué)品、資源投入或其他現(xiàn)有技術(shù)服務(wù)的交付模型； ? 局限于為展示或宣傳現(xiàn)有技術(shù)提供推廣服務(wù)的提案； ? 缺乏明確目標(biāo)或創(chuàng)新方法的大規(guī)模篩選

? 僅針對(duì)非生物性脅迫的提案（如干旱，酷熱等）。

六、本期主題——設(shè)計(jì)能優(yōu)化免疫接種系統(tǒng)的新手段

背景：

預(yù)防接種是世界上最具有成本效益的健康干預(yù)措施之一。然而，每年有大約兩千五百萬幼兒并未全面接種疫苗，更有至少兩百四十萬兒童死于疫苗可預(yù)防的疾病。

自從免疫接種計(jì)劃于20世紀(jì)70年代中期在全球中低收入國(guó)家開展以來，大多數(shù)國(guó)家在其免疫規(guī)劃中都一直使用相同的標(biāo)準(zhǔn)配置，包括六種疫苗：麻疹、破傷風(fēng)、白喉、百日咳、肺結(jié)核和脊髓灰質(zhì)炎。近十年來，由于疫苗接種對(duì)公共健康的影響愈發(fā)明顯，人們對(duì)新疫苗開發(fā)越來越感興趣，投入新疫苗開發(fā)和供應(yīng)的資金大幅增加。在未來十年內(nèi)，中低收入國(guó)家將有機(jī)會(huì)把許多能夠拯救生命的新疫苗引入其標(biāo)準(zhǔn)免疫方案，而在某些情況下，某些國(guó)家的免疫方案中所提供疫苗數(shù)量將會(huì)增加一倍。

對(duì)抗麻疹、白喉、破傷風(fēng)、百日咳及脊髓灰質(zhì)炎的傳統(tǒng)疫苗成本低廉，多在每劑$0.10美元至$0.25美元之間。由于用來發(fā)現(xiàn)和開發(fā)新疫苗的投資增加，同時(shí)有些制造工藝也相當(dāng)復(fù)雜，新疫苗的成本顯著增高，從1.00到15.00美元不等。這些增加的成本推動(dòng)我們需要改變疫苗推介方式。

隨著這些新疫苗的引進(jìn)，許多國(guó)家也面臨著新的挑戰(zhàn)——包括疫苗的供應(yīng)，以及保證其疫苗接種計(jì)劃能夠普及到新的目標(biāo)人群。在2010年，一批價(jià)值近一百萬美元的二十五萬劑五價(jià)疫苗在某國(guó)家的中央倉(cāng)庫(kù)放置過期，因?yàn)樵搰?guó)用來運(yùn)輸這些疫苗的系統(tǒng)未能準(zhǔn)備就緒。另一個(gè)國(guó)家則被迫推遲引入新疫苗的計(jì)劃，因?yàn)樾枰獙⑵鋰?guó)家存儲(chǔ)系統(tǒng)擴(kuò)大9倍，才能把該新疫苗加入其免疫接種計(jì)劃中。因此，中低收入國(guó)家必須想辦法改善其國(guó)家免疫接種計(jì)劃的物流系統(tǒng)，解決其供應(yīng)系統(tǒng)所面臨的日益沉重的負(fù)擔(dān)。

障礙

中低收入國(guó)家在疫苗物流與供應(yīng)系統(tǒng)上所面臨的主要挑戰(zhàn)如下：

? 新疫苗給中低收入國(guó)家的免疫接種計(jì)劃的物流和供應(yīng)系統(tǒng)帶來多方面的挑戰(zhàn)，有些新疫苗可能會(huì)占據(jù)供應(yīng)鏈的冷藏空間，要求更復(fù)雜的管理措施，并且其熱穩(wěn)定性可能無法適應(yīng)中低收入國(guó)家具有挑戰(zhàn)性的環(huán)境。

? 現(xiàn)有的疫苗供應(yīng)系統(tǒng)都是在多年以前設(shè)計(jì)的，因此，不少系統(tǒng)效率低下，其操作也與其他健康干預(yù)的供應(yīng)系統(tǒng)，和/或私營(yíng)部門完全隔離。再者，目前也不存在能夠持續(xù)地監(jiān)督這些系統(tǒng)以引導(dǎo)必要的調(diào)整與改進(jìn)的機(jī)制。

? 從國(guó)際層面到地區(qū)層面，制造商，捐款人，以及在某種程度上甚至各個(gè)國(guó)家本身都不重視疫苗供應(yīng)系統(tǒng)所消耗的能源，材料與工序?qū)Νh(huán)境造成的影響。

? 當(dāng)前的信息系統(tǒng)設(shè)計(jì)并沒有采用先進(jìn)的技術(shù)，而這些先進(jìn)的技術(shù)可以幫助指導(dǎo)免疫接種計(jì)劃的管理者們?cè)O(shè)計(jì)和執(zhí)行方案戰(zhàn)略，從而保證有足夠數(shù)量的疫苗，以正確的形式滿足需求。

? 中低收入國(guó)家目前的人力資源政策無法保證，在其各級(jí)管理機(jī)構(gòu)都有足夠數(shù)量的、能干、積極、有自主性的人員被授權(quán)克服目前免疫接種計(jì)劃供應(yīng)系統(tǒng)中新出現(xiàn)的挑戰(zhàn)。? 盡管免疫接種計(jì)劃獲得了巨大的成功，每五個(gè)孩子中仍然有一個(gè)孩子得不到基礎(chǔ)疫苗的接種。

我們希望尋求到的： 本課題旨在發(fā)掘新方法，在資源貧乏的環(huán)境中優(yōu)化疫苗接種計(jì)劃所需的物流與供應(yīng)系統(tǒng)的表現(xiàn)。鼓勵(lì)申請(qǐng)者重新審查用于運(yùn)輸疫苗的系統(tǒng)，設(shè)計(jì)創(chuàng)新的解決方案優(yōu)化這些系統(tǒng)的性能。我們所期待的申請(qǐng)?zhí)岚甘?，大膽?chuàng)新且明顯區(qū)別于當(dāng)前在調(diào)查研究階段或已經(jīng)采用的方法。在本課題下提交的解決方案，必須側(cè)重于國(guó)家的免疫接種相關(guān)的系統(tǒng)的操作性，并且具備在不同環(huán)境里規(guī)模性復(fù)制的潛力。

申請(qǐng)?zhí)岚钢斜仨毎軌蛑С痔嶙h的強(qiáng)有力的理論基礎(chǔ)，表明其對(duì)某個(gè)國(guó)家的情況和需求的清晰理解，提出明確的假設(shè)，以及相關(guān)計(jì)劃說明如何測(cè)試或驗(yàn)證有關(guān)設(shè)想。所提議的設(shè)想最終必須能夠轉(zhuǎn)化為實(shí)際的干預(yù)措施，且適用于資源有限的情況。

我們鼓勵(lì)申請(qǐng)人致力于解決以下領(lǐng)域的問題：

1.疫苗產(chǎn)品的特征

o 為了輔助中低收入國(guó)家、捐助者、以及采購(gòu)代理機(jī)構(gòu)在購(gòu)買疫苗時(shí)做出明智的判斷與抉擇，并優(yōu)化其疫苗免疫策略規(guī)劃，設(shè)計(jì)一系列工具使其能夠合理評(píng)估某些特定類型的疫苗產(chǎn)品的系統(tǒng)成本和效益，而不是僅僅基于產(chǎn)品的價(jià)格。o 成本低，用于藥水瓶上的可以顯示對(duì)高溫的累積接觸，以及其可經(jīng)受的最高溫度的指示器。

o 能夠避免疫苗的意外冷凍，和/或能在儲(chǔ)存與使用之時(shí)保證已被開封的多劑量疫苗藥瓶維持無菌狀態(tài)的，而無關(guān)于該疫苗配方的手段

2.供應(yīng)系統(tǒng)設(shè)計(jì)

設(shè)計(jì)創(chuàng)新的解決方案，使衛(wèi)生工作者能夠輕松地將更多的疫苗送達(dá)偏遠(yuǎn)和交通不便利的地區(qū)。譬如：在外展服務(wù)中降低對(duì)冰塊的需求；設(shè)計(jì)新的方法以備遇到需要長(zhǎng)期儲(chǔ)存疫苗的情況；利用其他可供選擇的交通資源來配送疫苗；無須使用冰塊或冷水袋，可以在使用地冷卻重組疫苗的方法，等等。

o 在國(guó)內(nèi)示范試點(diǎn)，證明通過疫苗免疫計(jì)劃的供應(yīng)系統(tǒng)與其他健康預(yù)防或私營(yíng)領(lǐng)域的供應(yīng)系統(tǒng)之間的協(xié)同合作，能夠取得更富成效的結(jié)果。

o 將全球定位信息軟件工具集成于供應(yīng)系統(tǒng)設(shè)計(jì)中，以優(yōu)化物流運(yùn)輸?shù)穆窂胶洼斔秃骄€，并減少對(duì)環(huán)境的影響。

3.對(duì)環(huán)境造成的影響

o 設(shè)計(jì)一個(gè)試驗(yàn)性提案，展示如何在設(shè)計(jì)供應(yīng)系統(tǒng)和選擇新技術(shù)時(shí)，能減少對(duì)環(huán)境的影響同時(shí)保證成本效益。

o 試點(diǎn)試驗(yàn)要求使用對(duì)環(huán)境能夠安全處理醫(yī)學(xué)廢品，尤其是注射器廢品

以及對(duì)環(huán)境安全負(fù)責(zé)的新技術(shù)或手段。

4.信息系統(tǒng)

o 演示一種新穎，低成本的解決方案，能滿足低收入國(guó)家對(duì)于中低層級(jí)別疫苗供應(yīng)系統(tǒng)的基本運(yùn)營(yíng)信息需求（請(qǐng)注意：基于或完全依賴SMS平臺(tái)來寄發(fā)提示或者通知的提案將不會(huì)被納入考慮）o 展示低成本專用設(shè)備（即：盈利機(jī)構(gòu)在銷售網(wǎng)點(diǎn)使用的條碼閱讀設(shè)備）的優(yōu)點(diǎn)，將這類設(shè)備在在低收入環(huán)境中使用，可以滿足基本物流管理數(shù)據(jù)的需求。

5.人力資源

o 開發(fā)創(chuàng)新工具和手段，輔助國(guó)家工作人員改善他們?cè)谝呙绻?yīng)系統(tǒng)方面的表現(xiàn)

6.公眾對(duì)疫苗接種的接受度

o 設(shè)計(jì)創(chuàng)新、可負(fù)擔(dān)及可持續(xù)的方法，以增加理解和擴(kuò)展領(lǐng)域，幫助公眾接受免疫接種。

o 設(shè)計(jì)創(chuàng)新方法，能夠在低收入地區(qū)化解對(duì)疫苗接種的誤解與不準(zhǔn)確訊息。

對(duì)以下提案我們將不予考慮： o 申請(qǐng)?zhí)岚笩o法直接解決上述任何領(lǐng)域的問題；

o 申請(qǐng)?zhí)岚笡]有清晰明確的目標(biāo)或目標(biāo)的質(zhì)量、效率以及/或有效性無法確切地評(píng)估；

o 臨床前或臨床研究：關(guān)于疫苗管理或運(yùn)輸設(shè)備的提案；旨在提高疫苗的穩(wěn)定性或配方的提案；提案涉及動(dòng)物實(shí)驗(yàn)或人類受試者的臨床試驗(yàn)；

o 僅對(duì)目前的方法或傳統(tǒng)的解決方案進(jìn)行量變的提高。譬如：基于或完全依賴SMS平臺(tái)來寄發(fā)提示或者通知的提案。

o 不適用于中低收入國(guó)家的方法；

o 申請(qǐng)?zhí)岚钢械男碌慕鉀Q方案不具備被廣泛使用或規(guī)模性擴(kuò)展的潛力;o 申請(qǐng)?zhí)岚钢袥]有描述或概括對(duì)下游供應(yīng)系統(tǒng)的影響;o 申請(qǐng)?zhí)岚竷H適用于個(gè)別廠家的產(chǎn)品或涉及特定產(chǎn)品的改善措施。

七、本期主題——在全球健康的重點(diǎn)領(lǐng)域探索新方案

機(jī)會(huì)：

我們的全球健康項(xiàng)目旨在創(chuàng)造和改善特定的預(yù)防、診斷和治療手段，從而應(yīng)對(duì)那些感染母嬰和兒童的傳染性疾病和癥狀，使其不再對(duì)這些人群的健康和營(yíng)養(yǎng)造成危害。我們主要通過三個(gè)方法達(dá)到這個(gè)目的：1)發(fā)現(xiàn)、填補(bǔ)相關(guān)領(lǐng)域的知識(shí)空白，在通向健康方案的關(guān)鍵道路上掃除前進(jìn)的障礙；2）建立新的技術(shù)平臺(tái)，用它來加快研究、拉近目標(biāo)，或者開發(fā)能在資源貧乏的環(huán)境中使用的產(chǎn)品；3）通過投資富有改革性的創(chuàng)意，解決全球性的健康難題。我們的所有投資都出于一個(gè)需要，那就是設(shè)計(jì)出能在發(fā)展中國(guó)家孕育、推廣和持續(xù)的方案，并將這些方案付諸實(shí)踐。

我們尋找的是： ? 能在全球健康的重點(diǎn)領(lǐng)域發(fā)揮作用的方案，這些領(lǐng)域包括瘧疾、艾滋病、結(jié)核、肺炎、腸道疾病和痢疾、脊髓灰質(zhì)炎、母嬰健康、及/或計(jì)劃生育；

? ? 對(duì)現(xiàn)有技術(shù)的顛覆或者改進(jìn)；

低成本方案，亦即為人均日生活費(fèi)用低于1美元的人群設(shè)計(jì)的方案，要求在低收入和中等收入國(guó)家可執(zhí)行并有擴(kuò)展空間。； ? 包含清晰、可驗(yàn)證的科學(xué)計(jì)劃的項(xiàng)目，它們必須（i）基于可驗(yàn)證的假說，（ii）附帶一份計(jì)劃，闡明測(cè)試或者驗(yàn)證的方法，（iii）在一期研究中取得明確且可以合理解釋的數(shù)據(jù)，我們將基于此考核是否給予二期研究的撥款。

我們強(qiáng)烈建議申請(qǐng)人采取下面的一種或幾種方向： ? 與以往任何探索大挑戰(zhàn)的主題（比如促進(jìn)疫苗功效的營(yíng)養(yǎng)、誘導(dǎo)黏膜免疫系統(tǒng)保護(hù)新生兒的新方法等）形成交叉；

? 利用發(fā)達(dá)國(guó)家重點(diǎn)贊助下產(chǎn)生的知識(shí)或技術(shù)，將其應(yīng)用于我們的全球健康重點(diǎn)領(lǐng)域；

? 運(yùn)用跨學(xué)科方法從事全球健康領(lǐng)域中受到忽視的技術(shù)學(xué)科的研究。

下列情況，不予贊助： ? ? ? 您的創(chuàng)意或方案不符合上述的蓋茨基金會(huì)的全球健康重點(diǎn)領(lǐng)域和戰(zhàn)略方向； 您的創(chuàng)意沒有一個(gè)表達(dá)清晰、能夠驗(yàn)證的假說為基礎(chǔ)；

您的方向僅僅是對(duì)傳統(tǒng)方案的改進(jìn)（例如：針對(duì)疫苗研發(fā)、供應(yīng)方面的現(xiàn)有研究，即便是對(duì)現(xiàn)有技術(shù)及工具的拓展、改進(jìn)和整合）；

? ? 您所開展的是基礎(chǔ)研究，且該研究對(duì)解決全球健康問題沒有明確的目標(biāo)； 您的研究是基于傳統(tǒng)的小分子方法和生物治療方法的變化（比如對(duì)新化學(xué)個(gè)體的篩選、鑒定驗(yàn)證、或?qū)λ幬锆熜У臏y(cè)試），且得出的藥物治療方法不適用于瘧疾或結(jié)核疾病。

? ? 您的項(xiàng)目?jī)H限于行為改變/教育目的（比如培訓(xùn)項(xiàng)目、獎(jiǎng)學(xué)金項(xiàng)目、教育項(xiàng)目等）； 您的項(xiàng)目?jī)H限于基礎(chǔ)設(shè)施建設(shè)或能力建設(shè)舉措； ? ? 您的方法包含不可接受的下游安全風(fēng)險(xiǎn)（比如對(duì)產(chǎn)品開發(fā)構(gòu)成障礙）； 您的研究針對(duì)本輪挑戰(zhàn)賽的其他主題。

For more specific information about the foundation’s strategies in the priority Global Health areas, see:

欲了解蓋茨基金會(huì)全球健康重點(diǎn)領(lǐng)域戰(zhàn)略的詳細(xì)信息，請(qǐng)?jiān)L問下面的網(wǎng)址：

http://004km.cn/global-health/Pages/global-health-strategies.aspx

八、往屆中國(guó)獲獎(jiǎng)?wù)?/p>

2011年

· 寧靖（石家莊經(jīng)濟(jì)學(xué)院）：研究利用風(fēng)力和太陽能驅(qū)動(dòng)設(shè)備處理糞便污水系統(tǒng)，為欠發(fā)達(dá)地區(qū)的居民提供一種廉價(jià)、穩(wěn)固、易組裝的新型馬桶。

· 張勇（中國(guó)疾病預(yù)防控制中心病毒病研究所）：研究中國(guó)VDPVs基因和抗原對(duì)溫度的敏感性和進(jìn)化速率，以治療早期發(fā)現(xiàn)的脊髓灰質(zhì)炎。

· 范彬（中國(guó)科學(xué)院）：研究真空源分離與廢物資源利用的低成本分散式生活衛(wèi)生系統(tǒng)，設(shè)計(jì)“真空廁所”，節(jié)水節(jié)電，廢物回收。

中科院研究員靠污水處理技術(shù)獲全球公益獎(jiǎng)項(xiàng)，《公益時(shí)報(bào)》2011.5.24。

· 陳宏翔（武漢協(xié)和醫(yī)院）：開發(fā)一種X線敏感熒光材料的稀土納米顆粒，連接針對(duì)HIV病毒的靶向單鏈抗體，對(duì)AIDS進(jìn)行X射線激發(fā)的間接光動(dòng)力學(xué)治療。

武漢協(xié)和醫(yī)院探索用X線消滅HIV 獲蓋茨基金會(huì)資助，《中新網(wǎng)》2011.5.4

2010年

· 唐勁天（清華大學(xué)）：應(yīng)用熱療方法進(jìn)行血吸蟲病的防治，使血吸蟲被殺死在人體的皮膚和腹腔中。

清華科研團(tuán)隊(duì)獲蓋茨基金會(huì)“探索大挑戰(zhàn)”計(jì)劃資助，《科學(xué)網(wǎng)》，2010.12.17 蓋茨征集奇思妙想——記清華大學(xué)獲獎(jiǎng)團(tuán)隊(duì)，《北京科技報(bào)》2010.12.6

· 王國(guó)治（中國(guó)藥品生物制品檢定所）：研究一種簡(jiǎn)單獨(dú)特的篩選耐藥結(jié)核病的方法。

· 劉暢和孔曉紅（南開大學(xué)）：通過分子生物學(xué)技術(shù)制作HIV的干擾病毒，干擾HIV在病人體內(nèi)的復(fù)制，從而延長(zhǎng)艾滋病病人的生命。獲蓋茨基金資助 南大講師劉暢 ：十萬美金只是讓我起步，《每日新報(bào)》，2010.5.22 南開教師大膽構(gòu)想獲蓋茨十萬美金資助，《中國(guó)青年報(bào)》，2010.5.13

· 黨宏月（中國(guó)石油大學(xué)）：研究肺炎早期感染是否產(chǎn)生特征生物標(biāo)識(shí)物分子，并研制一種呼吸傳感器裝置，用以捕捉和分析這些標(biāo)志性化合物，從而作為資源匱乏環(huán)境條件下的一種肺炎診斷方法。

2009年

· 譚光宏（海南醫(yī)學(xué)院熱帶病重點(diǎn)實(shí)驗(yàn)室）：計(jì)劃通過對(duì)免疫加強(qiáng)型減毒孢子的研究，更好地開發(fā)有效的熱帶病疫苗。

十萬美元驗(yàn)證一個(gè)新點(diǎn)子，《健康報(bào)》，2009.6.19

· 陳揚(yáng)超（香港中文大學(xué)）：擬建立一種針對(duì)流感病毒在家禽雞只中侵入及復(fù)制的慢病毒載體，并利用該載體對(duì)雞只進(jìn)行基因改造，以減少禽流感的發(fā)病率，最終減低人類感染禽流感的機(jī)會(huì)。

香港中文大學(xué)抗禽流感研究獲頒10萬美元資助，《中新網(wǎng)》，2009.5.6

2008年

· 高謙（復(fù)旦大學(xué)上海醫(yī)學(xué)院）：領(lǐng)導(dǎo)本科生楊順遙和研究生王川，致力于研究MicroRNA在潛伏感染到活動(dòng)性結(jié)核病中的作用。

兩頁紙換來十萬美金，《中國(guó)青年報(bào)》，2008.11.5

Global hunts for off-beat research，《中國(guó)日?qǐng)?bào)》，2009.4.3 · 陳志偉（香港大學(xué)艾滋病研究）：致力于研究一種新型的艾滋疫苗，利用它阻斷經(jīng)性接觸傳播的艾滋病毒。這項(xiàng)計(jì)劃的概念驗(yàn)證將在恒河猴艾滋動(dòng)物模型上進(jìn)行。

Chinese scientists win Gates grants，《中國(guó)日?qǐng)?bào)》，2008.10.28

第四篇：高西慶-杜克大學(xué)法學(xué)院2014屆畢業(yè)典禮演講

高西慶校友在美國(guó)杜克大學(xué)法學(xué)院2014屆畢業(yè)典禮上的演講 在剛剛結(jié)束的美國(guó)杜克大學(xué)法學(xué)院2014屆畢業(yè)典禮上，86屆畢業(yè)生高西慶校友深情回憶了他年輕時(shí)修鐵路不忘學(xué)習(xí)英語，后來到Duke法學(xué)院求學(xué)住在圖書館，再后來回國(guó)建立中國(guó)資本市場(chǎng)的人生經(jīng)歷，并給畢業(yè)生們提出了建議：保持開放的心態(tài)，肯吃苦、不過分追求物質(zhì)生活，最重要的是愿意嘗試別人沒有走過的道路。不忘初心，方得始終。今天我們?nèi)目l(fā)高老師演講全文(中英文對(duì)照)，以饗讀者。I was going to speak today about the necessity for an open-mind as you approach new opportunities, new environment and new paradigm, the need to have stamina in times of difficulty and to not be afraid to take the road less travelled.But I believe most of you know this or you wouldn’t be here today in the first place.我今天本來想跟大家講講未來當(dāng)你們面對(duì)新的機(jī)會(huì)、新的環(huán)境以及新的模式時(shí)保持開放心態(tài)的必要性，以及遇到困難時(shí)應(yīng)該怎樣保持堅(jiān)持不懈的努力和擁有另辟蹊徑的勇氣?？墒牵蚁嘈旁谧拇蟛糠秩硕家呀?jīng)十分明白這些道理，否則你們不會(huì)取得今天的成績(jī)。

So I'm just going to give you a piece of avuncular advice, tell my story and be boring:

所以我只想從一個(gè)長(zhǎng)者的角度給你們一點(diǎn)建議，講講我的故事，或許這會(huì)比較無聊。

Close to thirty years ago, I was where you are today and only a few years before that, it would have seemed impossible to me that I would ever sit where you are today.You have earned this seat, through intelligence, diligence and discipline, my deepest congratulations to all of you.For all the cynicism in the world today, especially given how people perceive the practice of law, I encourage all of you to preserve your optimism, idealism and passion for what you do.大約30年前，我正坐在你們現(xiàn)在坐的位置上；如果再倒回幾年的話，我完全不敢想像自己有朝一日會(huì)成為你們其中的一員。你們通過自己的才智、勤奮和自律贏得了坐在今天畢業(yè)典禮上的資格，我衷心地祝賀你們。面對(duì)現(xiàn)今橫行于世的犬儒主義，尤其是人們對(duì)整個(gè)法律行業(yè)的負(fù)面看法，我鼓勵(lì)你們不要丟掉做自己想做事時(shí)的那份樂觀、理想以及激情。不忘初心，方得始終。You have proven that you have a lot to offer this world, now you need to prove you can make a difference, whether that be in the courtroom, classroom, NGO or office lead by example because ANYTHINGIS POSSIBLE!I want to share with you some of my experience in the hopes that it encourages you to not accept barriers at any cost.各位同學(xué)已經(jīng)證明你們有能力為這個(gè)世界貢獻(xiàn)良多，但是現(xiàn)在你需要去證明你確實(shí)可以通過努力讓這個(gè)世界變得不同。這種變化可以發(fā)生在法庭上、教室里，也可以發(fā)生在民間組織或是政府部門之中，因?yàn)橐磺薪杂锌赡埽∥蚁牒湍銈兎窒硪恍┪业慕?jīng)歷，希望以此鼓勵(lì)你們面對(duì)挑戰(zhàn)絕不退縮，勇往直前。

As a teenager, I was sent to a railroad construction site deep in the mountains in Western China.Food was rationed and workload was heavy.However, what made it more unbearable was the lack of knowledge and information.I devoured every piece of paper that had any word on it, like a hungry man.Together with a few co-workers we started a study group called “The Communist Laborer's Night School”, with the few old text books we brought with us, and a radio we used to learn English from VOA and BBC, at the risk of imprisonment for listening to “enemy stations”.當(dāng)我還是一個(gè)十幾歲少年的時(shí)候，我被送到中國(guó)西部的大山區(qū)里修建鐵路。在那里，食物實(shí)行配給制并且工作強(qiáng)度很大，所以我們總是處于饑餓狀態(tài)。但是，更加讓人痛苦的是知識(shí)與信息的缺失。我貪婪地去看每張偶爾得到的寫有字的紙片，如饑似渴。我還和其他幾位工友們成立了一個(gè)“共產(chǎn)主義勞動(dòng)夜校”。我們一同學(xué)習(xí)一些舊課本，冒著被判刑的風(fēng)險(xiǎn)用一臺(tái)收音機(jī)聽“敵國(guó)電臺(tái)”：從“美國(guó)之音”和BBC學(xué)習(xí)英語。After 3 years of hard labor and a head injury, I was given a job in an artillery factory making machine guns.I biked about 10 miles twice a week to learn English taught in the Radio Engineering School of a university in Xi'an.Most of the 200 people quitted the class during the one-year study, and I was one of the dozen remaining, together with the chief engineer of my factory, who later put in a strong recommendation for me to go to college in Beijing, without having ever been to a high school.經(jīng)過三年繁重的勞動(dòng)和一次腦部受傷，我被分配到西安一家兵工廠制造機(jī)關(guān)槍。我每周兩次下班后騎自行車去10英里外一所大學(xué)的無線電工程系學(xué)習(xí)英語。在這一年的學(xué)習(xí)中，200多名學(xué)員中的大多數(shù)并沒有堅(jiān)持。但是我是那堅(jiān)持下來的十幾個(gè)人之一，一同留下來的還有我工廠里的總工程師。他后來在我甚至沒有上過高中的情況下強(qiáng)烈推薦我去北京讀大學(xué)。

After graduating from both college and law school in BJ, I was sent as an exchange scholar to work in a law firm in California.Boy I remember the cultural shock I had when I first arrived in SF in 1982!There I realized that my knowledge of law was utterly inadequate to deal with international transactions, which I was supposed to teach back in Beijing.I decided to go through the hardship of studying for a JD degree in the US.That started my honey-decades with Duke law, which gave me a full scholarship and a fuller education in American law.從對(duì)外經(jīng)貿(mào)大學(xué)的法學(xué)碩士班畢業(yè)后，我獲得了去加州一家律所實(shí)習(xí)的交換機(jī)會(huì)。我仍然記得1982年當(dāng)我第一次抵達(dá)舊金山時(shí)所能感受到的文化沖擊。在那里，當(dāng)處理一些有關(guān)國(guó)際交易的案子時(shí)，我意識(shí)到自己有關(guān)美國(guó)法律的知識(shí)非常匱乏，而這卻是我回國(guó)之后準(zhǔn)備教授的。我決定在美國(guó)咬著牙讀一個(gè)法學(xué)博士學(xué)位。杜克法學(xué)院資助了我全額獎(jiǎng)學(xué)金讓我能夠系統(tǒng)地學(xué)習(xí)美國(guó)法律，從此開啟了我和杜克法學(xué)院長(zhǎng)達(dá)三十年源遠(yuǎn)流長(zhǎng)的甜蜜之旅。

I was once asked by a hard-struggling law student from China why I seemed so happy and content with my studies then, living mostly in the law library.I answered, if you have experienced the deprivation of knowledge for so long as I have, you would, too, view this place as the heaven of learning.I said that despite the many occasions when a few professors would vote against granting the scholarship to a “red Chinese”, or some fellow students spoke right in my face that they were “abhorred” by the Chinese communist system.When I was later asked of a similar question as a junior associate in the sweat shop of a Wall Street law firm, I happily told the fellow associate that Vladimir Lenin taught me to learn your skills so to dig the grave for capitalism.曾經(jīng)有一個(gè)深受法學(xué)院學(xué)習(xí)壓力痛苦折磨的中國(guó)學(xué)生問過我這樣一個(gè)問題：“你幾乎成天以圖書館為家，為什么還那么開心和滿足？”我回答說，如果你像我那樣，經(jīng)歷過如此之長(zhǎng)的缺乏精神食糧的歲月，那么你同樣會(huì)把這地方當(dāng)做是求知的天堂。當(dāng)然求學(xué)過程中也有很多不盡人意之處，比如有那么幾位教授反對(duì)給我這個(gè)來自紅色中國(guó)的人發(fā)獎(jiǎng)學(xué)金，或者有幾位學(xué)生曾當(dāng)面對(duì)我說他憎恨中國(guó)的共產(chǎn)主義制度。我后來在華爾街一所律所里當(dāng)律師的時(shí)候，也被問到這個(gè)問題時(shí)，我很開心地回答道，列寧教導(dǎo)我要學(xué)習(xí)西方的先進(jìn)知識(shí)，才可以為資本主義挖掘墳?zāi)埂?/p>

The ensuing 1987 financial crisis jolted me to an opposite direction, though.I was so fascinated by the intricacies of the capitalistic financing machines that I decided to study it carefully and try to transplant it to my own home country.I went back to China in the summer of 1988, after visiting most of the stock exchanges in Europe and some in Asia, in a seemingly fool-hardy effort to persuade the Chinese government forthe establishment of a capital market.然而，隨后1987年的金融危機(jī)卻將我拉向了另外一個(gè)方向。我對(duì)這精妙的資本主義籌融資機(jī)器體系產(chǎn)生了巨大的興趣，所以我決定認(rèn)真仔細(xì)地研究它并且將這架機(jī)器移植到我自己的祖國(guó)。在自費(fèi)調(diào)研過歐洲以及亞洲大部分證券交易所后，我于1988年夏天回國(guó)，以近乎愚公移山的努力說服中國(guó)政府建立中國(guó)的資本市場(chǎng)。

Among all the people who were skeptical of our idea, was an American consul in Beijing.After suspiciously questioning my intention to have gone back to China and hearing my explanation about my ambition to start the stock market there, he said, this is all BS, and tore up my application forms.This is in early 1990, when I applied to come to teach a short course at Duke law.By the end of that year, we have helped the opening of two stock exchanges, the SHSE and the SZSE, which have a combined market cap of several trillion dollars today.Two years after, the unintended consequences started to show and the central government finally adopted our proposal of setting up the regulatory agency and persuaded me to join it.在所有質(zhì)疑我這個(gè)想法的人群中，有一位是駐北京的美國(guó)領(lǐng)事。在懷疑我回中國(guó)的動(dòng)機(jī)并且聽完我想要在那里建立股票市場(chǎng)的想法后，他說，這完全是扯淡，并且撕碎了我美國(guó)簽證的申請(qǐng)表。記得那是1990年初，我當(dāng)時(shí)去申請(qǐng)美國(guó)簽證回杜克法學(xué)院教幾周課。當(dāng)年年底，中國(guó)自己的兩個(gè)證券交易所就建成了：上海證交所和深圳證交所。今天，這兩家證券交易所交易的股票總市值達(dá)到上萬億美金。隨后的兩年，中央政府最終接受了我們的提議并啟動(dòng)成立了證券市場(chǎng)監(jiān)管機(jī)構(gòu)，并且勸說我加入其中。Being a regulator is like being a matchmaker, when the marriage is successful, the couple would think it's their own good fortune, will be busy enjoying themselves and very seldom grateful to you.But if anything goes wrong, then both sides blame you for it.I got just that sort of treatment, blamed all the time, for good or bad reasons.I was yanked out of the agency to run the newly established Social Security Fund in 2003, and then, 4 and half years later, the Sovereign Wealth Fund.After almost 7 years serving as an investor, I'm finally relieved of my duty and allowed to retire to do what I love the most, i.e., working with young people every day, teaching and, more importantly, learning.監(jiān)管者的角色就好比是媒人，如果做媒成功，男女雙方會(huì)認(rèn)為這是他們自己的好運(yùn)氣，沉溺于愛河中而沒有時(shí)間來感謝你。但一旦失敗，雙方都會(huì)指責(zé)你的不是。我就獲得了那樣的待遇：不管是什么樣的原因，總是被罵。2003年，我被調(diào)離證監(jiān)會(huì)成為新成立的全國(guó)社會(huì)保障基金的負(fù)責(zé)人，四年之后，又成為中投公司的總經(jīng)理。在七年的投資生涯之后，我總算可以卸下身上的責(zé)任并且獲準(zhǔn)退休去干我最想干的事情——那就是每天和年輕人在一起，教授他們，更重要的是，向他們學(xué)習(xí)。

Why do I want to tell you the boring story of a personal life? Because I can't help offering you my advice, having made so many mistakes and suffered so many detours.Here are the few things I learned in life in the vain hope that you would avoid them.為什么我想向你們講述我自己沒有多大意思的人生經(jīng)歷？因?yàn)槲以诜高^如此多錯(cuò)誤、走過無數(shù)次彎路之后，忍不住想提供給你們一些我的建議。下面就是我的一點(diǎn)人生體會(huì)，希望你們能夠有所感悟，避免走我所走過的彎路。

1.Different views, different people, different culture and different ideology may not necessarily a bad thing.They just teach you to be more tolerant and open minded.Vive la difference, as the French would say.1.不同的思想、不同的人、不同的文化以及不同的意識(shí)形態(tài)或許并不是一件壞事。他們只是在教你更加寬容，保持更加開放的心態(tài)。就像法國(guó)人說的那樣，Vive la difference（差別萬歲）。

2.Taking hardship is not necessarily a bad thing, it may pay in the long run.Of course in the long run we will all be dead, as Maynard Keynes said.And that's why we need the next suggestion.2.吃苦或許不是一件壞事，總有一天你會(huì)獲得回報(bào)。當(dāng)然凱恩斯也說過：從長(zhǎng)遠(yuǎn)來看，我們都會(huì)死的。但這也就是為什么我們需要下一個(gè)建議。

3.Taking the road less travelled is not necessarily a bad thing, it just makes your life much more interesting.Let's try to live an interesting and significant life.3.另辟蹊徑走自己的路或許不是一件壞事，這只是意味著我們的生活會(huì)更加精彩。讓我們嘗試去過一種精彩并且有意義的生活。

4.Setting high material demands in this world today is not necessarily a good thing, as it may keep you from realizing your ideals or keeping your vision.在當(dāng)今社會(huì)，對(duì)物質(zhì)生活的過分追求或許不是一件好事。因?yàn)檫@將使你遠(yuǎn)離夢(mèng)想，不能開拓你的視野。

I want to leave you today with the words of the great American poet, Max Ehrmann because he said it infinitely better than I can.Hope you guys can remember this as you go forth.最后，我想送給你們偉大的美國(guó)詩人Max Ehrmann的詩篇，他講得比我好多了。我希望你們?cè)谇靶械牡缆飞希軌蛴涀∵@首詩。

Go placidly amid the noise and haste, and remember what peace there may be in silence.As far as possible without surrender be on good terms with all persons.Speak your truth quietly and clearly;and listen to others, even the dull and the ignorant;they too have their story.Avoid loud and aggressive persons, they are vexations to the spirit.If you compare yourself with others, you may become vain and bitter;for always there will be greater and lesser persons than yourself.Enjoy your achievements as well as your plans.Keep interested in your own career, however humble;it is a real possession in the changing fortunes of time.Exercise caution in your business affairs;for the world is full of trickery.But let this not blind you to what virtue there is;many persons strive for high ideals;and everywhere life is full of heroism.Be yourself.Especially, do not feign affection.Neither be cynical about love;for in the face of all aridity anddisenchantment it is as perennial as the grass.Take kindly the counsel of the years, gracefully surrendering the things of youth.Nurture strength of spirit to shield you in sudden misfortune.But do not distress yourself with dark imaginings.Many fears are born of fatigue and loneliness.Beyond a wholesome discipline, be gentlewith yourself.You are a child of the universe, no less than the trees and the stars;you have a right to be here.And whether or not it is clear to you, no doubt the universe is unfolding as it should.Therefore be at peace with universe, and whatever your labors and aspirations, in the noisy confusion of life keep peace with your soul.With all its sham, drudgery, and broken dreams, it is still a beautiful world.Be cheerful.Strive to be happy.在嘈雜和匆忙中，平靜地前行吧，也別忘了在寂靜中，能找到多好的安寧。

可以的話，盡量不放棄原則而與所有人和睦相處。

細(xì)語清晰地說出你的肺腑之言，也聆聽別人的說話，別人的話縱然又枯燥又無知，總會(huì)有他們的故事。

避開大聲說話和好斗的人；他們是擾亂心性的人。

不要跟其他人比較，否則可能變得虛榮自負(fù)或忿忿不平，因?yàn)橐欢ㄓ腥吮饶銈ゴ螅惨欢ㄓ腥吮饶忝煨　?/p>

享受計(jì)劃，也享受成就。無論自己的事業(yè)有多卑微，維持對(duì)它的興趣；

在一生多變的命運(yùn)中，它是你真正擁有的東西。

謹(jǐn)慎處理生意，因?yàn)檫@世界充斥著欺詐。

但是，不要因此而看不見人間美德； 很多人為崇高理想而奮斗，生命到處都有英勇的事跡。

做你自己。

尤其不要虛情假意。但也不要把愛視為虛偽；

因?yàn)楸M管生命有時(shí)枯燥乏味、有時(shí)令人迷醉，愛，卻如青草般日久常在。不輕視因年老而獲得的閱歷，并得體地舍棄年輕時(shí)擁有的東西。培育心靈上的力量，以面對(duì)突然而來的不幸。

但不要杞人憂天以致心神不寧。眾多的恐懼，源自疲乏和孤獨(dú)。要既不踰矩，又善待自己。

你是宇宙的孩子，身份不次于樹木和星星；

身處這里是你的權(quán)利。不管你是否明白它的奧秘，毫無疑問宇宙在按其規(guī)律展現(xiàn)自己。因此，不管在你心中宇宙是什么模樣，和他和睦相處吧。

也不管你怎樣勞累和胸懷大志，在生命的煩囂和困惑中，要保持心靈上的安寧。

不管經(jīng)歷了多少偽善、苦役、和破碎的夢(mèng)，世界依然是美麗的。要保持輕松開朗。要努力讓自己快樂。

第五篇：jk羅琳2008哈佛畢業(yè)典禮演講

JK羅琳J(rèn)K羅琳2008哈佛大學(xué)畢業(yè)典禮上的演講

譯文_Juanz_新浪博客 如果您不僅去幫助強(qiáng)者，而且還會(huì)同情并幫扶弱者； 如果你會(huì)設(shè)身處地為不如你的人著想；

那么，您的存在將不僅是你家族的驕傲，也是無數(shù)因你幫助而過上幸福生活的人的驕傲。我們不需要魔法來改變世界，我們已經(jīng)擁有了需要的所有的力量。我們有能力想象會(huì)更好。

我的演講也接近尾聲了。對(duì)你們，我有最后一個(gè)希望，也是我在21歲時(shí)就一直在思考的。畢業(yè)那天坐在我身邊的朋友將是我終身的朋友。他們是我的孩子的教父母，是我在遇到麻煩是可以求助的人，是當(dāng)我用他們的姓名作為食死徒的名字而不會(huì)起訴我的朋友（譯者注：食死徒是哈利波特中人物在此指羅琳的朋友不會(huì)因?yàn)樗盟麄兊拿侄馄鹪V）。

在我們畢業(yè)的時(shí)候，我們因無盡的愛而在此相聚。我們有共同的永不再有的經(jīng)歷。當(dāng)然，如果我們中的任何人競(jìng)選首相，那么今天的照片將是極為寶貴的證明。所以，今天我可以給你們的，沒有比同伴的友誼更好的祝福了。

明天，我希望你們即使記不得我的名字，你還記得那些塞內(nèi)加，他是我在羅馬文學(xué)著作中結(jié)識(shí)的另一位哲學(xué)家。在我退出職業(yè)生涯后，尋找古老的生活智慧： 生活就像故事一樣，不在乎長(zhǎng)度，而在于質(zhì)量。這才是問題的關(guān)鍵。我在此祝大家生活愉快！非常感謝Thank you!

來源：(http://blog.sina.com.cn/s/blog_62b1cafa0100g5gn.html)-JK羅琳2008哈佛大學(xué)畢業(yè)典禮上的演講

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